Accumulation of DNA damages in aging Paramecium tetraurelia

@article{Holmes2004AccumulationOD,
  title={Accumulation of DNA damages in aging Paramecium tetraurelia},
  author={G. Holmes and N. R. Holmes},
  journal={Molecular and General Genetics MGG},
  year={2004},
  volume={204},
  pages={108-114}
}
SummaryParamecium tetraurelia cells of ages 4, 15, and 27 days were labeled with [14C]-thymidine. In addition, cells were grown clonally for 27 days (108 generations) and labeled with [14C]-thymidine in the presence of 0.5 or 7.5 μg/ml of mitomycin-C (MMC) or no MMC. These cells were gently deposited on a filter membrane, which impedes the passage of DNA strands. The cells were then lysed with detergents and the cellular components washed through the filters, leaving double-stranded DNA intact… Expand
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