Accumulation of Clostridium perfringens epsilon-toxin in the mouse kidney and its possible biological significance.

@article{Tamai2003AccumulationOC,
  title={Accumulation of Clostridium perfringens epsilon-toxin in the mouse kidney and its possible biological significance.},
  author={Eiji Tamai and Tetsuya Ishida and Shigeru Miyata and Osamu Matsushita and Hirofumi Suda and Shoji Kobayashi and Hiroshi Sonobe and Akinobu Okabe},
  journal={Infection and immunity},
  year={2003},
  volume={71 9},
  pages={5371-5}
}
In this paper we show that Clostridium perfringens epsilon-toxin accumulates predominantly in the mouse kidney, where it is distributed mainly in glomeruli, capillaries, and collecting ducts. Although some pycnotic and exfoliated epithelial cells were observed in distal tubuli and collecting ducts, there were no findings indicative of severe renal injury. Bilateral nephrectomy increased the mouse lethality of the toxin, suggesting that the kidney contributes to the host defense against the… CONTINUE READING

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