Accumulation of BNP7787 in human renal proximal tubule cells.

  title={Accumulation of BNP7787 in human renal proximal tubule cells.},
  author={Frederick H. Hausheer and Dianer Ding and Dakshine Shanmugarajah and Betsy D. Leverett and Qun Huang and X. Chen and Harry Kochat and Philippe Y. Ayala and Pavankumar N. Petluru and April Rae Parker},
  journal={Journal of pharmaceutical sciences},
  volume={100 9},
  • Frederick H. Hausheer, Dianer Ding, +7 authors April Rae Parker
  • Published in
    Journal of pharmaceutical…
  • Chemistry, Medicine
  • BNP7787, an investigational drug undergoing global Phase III development, appears to have potential advantages over other cytoprotective compounds that have been evaluated for preventing and mitigating cisplatin-induced nephrotoxicity. Herein, we characterized the in vitro accumulation of BNP7787 in human renal proximal tubule cells (HK-2) in which cisplatin is known to be taken up and accumulate. HK-2 cells were incubated with pharmacological concentrations of BNP7787 for varying times… CONTINUE READING

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