Accumulation of B lymphocytes with a naive, resting phenotype in a subset of hepatitis C patients.

@article{Ni2003AccumulationOB,
  title={Accumulation of B lymphocytes with a naive, resting phenotype in a subset of hepatitis C patients.},
  author={Jianhua Ni and Edgardo Hembrador and Adrian M Di Bisceglie and I M for the New Paradigm of HCV Therapy Meeting Part Jacobson and Andrew H. Talal and David Butera and Charles M. Rice and Thomas J. Chambers and Lynn B. Dustin},
  journal={Journal of immunology},
  year={2003},
  volume={170 6},
  pages={3429-39}
}
Chronic infection with hepatitis C virus (HCV) is associated with disturbances of B lymphocyte activation and function: autoantibody production, mixed cryoglobulinemia, and B cell lymphomas. It has been proposed that these abnormalities reflect chronic antigenic stimulation or aberrant signaling through the B cell coreceptor, the latter mediated by binding of the HCV E2 glycoprotein to CD81. To test this hypothesis, we measured expression of activation and differentiation markers on peripheral… CONTINUE READING

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