Accumulation of Ade+ reversions in isoauxotrophic strains ofSaccharomyces cerevisiœ allelic inRAD6 during adenine starvation

Abstract

A comparative method based on an analysis of accumulation of starvation-induced Ade+ reversions and cell death during adenine starvation was developed and exploited for estimating the role ofRAD6 in the starvation-induced reversions. It was shown that inactivation ofRAD6 function inSaccharomyces cerevisiœ markedly enhances the accumulation of Ade+ reversions, and therefore it is likely that this gene is taking part in maintaining the low level of starvation-induced mutations in yeast cells.

DOI: 10.1007/BF02898645

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@article{torchov1997AccumulationOA, title={Accumulation of Ade+ reversions in isoauxotrophic strains ofSaccharomyces cerevisiœ allelic inRAD6 during adenine starvation}, author={Zuzana {\vS}torchov{\'a} and Andrea Gil and Blanka Janderov{\'a} and Josef Vlas{\'a}k and Vladim{\'i}r Vondrejs}, journal={Folia Microbiologica}, year={1997}, volume={42}, pages={47-51} }