Accumulation of Acrolein–Protein Adducts after Traumatic Spinal Cord Injury

@article{Luo2005AccumulationOA,
  title={Accumulation of Acrolein–Protein Adducts after Traumatic Spinal Cord Injury},
  author={Jian Luo and Koji Uchida and Riyi Shi},
  journal={Neurochemical Research},
  year={2005},
  volume={30},
  pages={291-295}
}
Reactive oxygen species and resultant lipid peroxidation (LPO) have been associated with central nervous system trauma. Acrolein (2-propenal) and 4-hydroxynonenal (HNE) are the most toxic byproducts of LPO, with detrimental effects in various types of cells. In this study, we used immunoblotting techniques to detect the accumulation of protein-bound acrolein and HNE. We report that protein-bound acrolein and HNE were significantly increased in guinea pig spinal cord following a controlled… CONTINUE READING

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