Accumulation of 6-deoxyerythronolide B in a normal strain of Streptomyces erythreus and hydroxylation at carbon 6 of the erythranolide ring system by a soluble noninduced cell-free enzyme system.

@article{Corcoran1982AccumulationO6,
  title={Accumulation of 6-deoxyerythronolide B in a normal strain of Streptomyces erythreus and hydroxylation at carbon 6 of the erythranolide ring system by a soluble noninduced cell-free enzyme system.},
  author={John W. Corcoran and A M Vygantas},
  journal={Biochemistry},
  year={1982},
  volume={21 2},
  pages={263-9}
}
Erythronolide B, a presumed intermediate in the biosynthesis of the erythromycins, has been shown to be formed from 6-deoxyerythronolide B by hydroxylation at C-6. The substrate, a metabolite of a blocked mutant of Streptomyces erythreus and postulated to be an intermediate in the biosynthesis of the erythromycins, is found also in wild-type cultures of S… CONTINUE READING