Accumulation and toxicity of intravenously-injected functionalized graphene oxide in mice.

@article{Wen2015AccumulationAT,
  title={Accumulation and toxicity of intravenously-injected functionalized graphene oxide in mice.},
  author={Kai-Ping Wen and Ying-Chieh Chen and Chia-Hui Chuang and Hwan-You Chang and Chi-Young Lee and Nyan-Hwa Tai},
  journal={Journal of applied toxicology : JAT},
  year={2015},
  volume={35 10},
  pages={
          1211-8
        }
}
Graphene and its functionalized derivatives have recently emerged as interesting nanomaterials with promising applications in biomedicine. In this study, the long-term in vivo biodistribution of intravenously injected nanographene oxide (NGO) functionalized with poly sodium 4-styrenesulfonate (PSS) was systematically examined and the potential toxicity over 6 months of NGO-PSS nanoparticles was investigated. Our results showed that the nanoparticles mainly accumulate in the lung, liver and… CONTINUE READING
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