Accumulation and effects of nodularin from a single and repeated oral doses of cyanobacterium Nodularia spumigena on flounder (Platichthys flesus L.).

@article{Vuorinen2009AccumulationAE,
  title={Accumulation and effects of nodularin from a single and repeated oral doses of cyanobacterium Nodularia spumigena on flounder (Platichthys flesus L.).},
  author={P J Pekka J Vuorinen and Vesa O Sipi{\"a} and Krister M Karlsson and Marja Kein{\"a}nen and Ambrose Furey and Orla Allis and K. James and Ulla Perttil{\"a} and Eija Rimaila-P{\"a}rn{\"a}nen and Jussi Meriluoto},
  journal={Archives of environmental contamination and toxicology},
  year={2009},
  volume={57 1},
  pages={164-73}
}
Nodularin (NODLN) is a cyclic pentapeptide hepatotoxin produced by the cyanobacterium Nodularia spumigena, which occurs regularly in the Baltic Sea during the summer season. In this study flounder (Platichthys flesus L.) was orally exposed to NODLN either as a single dose or as three repeated doses 3 days apart. Liver and bile samples of the fish were taken 4 days after the last dose. Liver glutathione-S-transferase (GST) activity was also measured and the histopathology of the liver was… CONTINUE READING

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