Accumulating autofluorescent material as a marker for early changes in the spinal cord of the Mnd mouse.

@article{Messer1993AccumulatingAM,
  title={Accumulating autofluorescent material as a marker for early changes in the spinal cord of the Mnd mouse.},
  author={A. B. Messer and J A Plummer},
  journal={Neuromuscular disorders : NMD},
  year={1993},
  volume={3 2},
  pages={129-34}
}
The mouse mutant Motor neuron degeneration (Mnd) displays an adult-onset progressive degeneration of upper and lower motor neurons, with mild symptoms recognizable at 6 months, leading to spastic paralysis and premature death at 10-12 months on the C57B1/6 background. Despite this late onset, abnormally-accumulating autofluorescent material can be seen in both the spinal cord and other regions as early as the first month. This pigmented material is present in both increasing numbers of cells… CONTINUE READING