Accumbens Homer2 Overexpression Facilitates Alcohol-Induced Neuroplasticity in C57BL/6J Mice

@article{Szumlinski2008AccumbensHO,
  title={Accumbens Homer2 Overexpression Facilitates Alcohol-Induced Neuroplasticity in C57BL/6J Mice},
  author={K K Szumlinski and Alexis W Ary and Kevin D. Lominac and Matthias Klugmann and Tod E. Kippin},
  journal={Neuropsychopharmacology},
  year={2008},
  volume={33},
  pages={1365-1378}
}
Homer proteins are integral components of the postsynaptic density that are necessary for alcohol-induced neuroplasticity within the nucleus accumbens (NAC). In this report, we describe the effects of chronic alcohol consumption upon NAC Homer expression and investigate the functional consequences of mimicking the alcohol-induced changes in Homer expression vis-à-vis alcohol-induced changes in NAC neurochemistry and behavior. Chronic alcohol consumption under continuous access (3 months; daily… CONTINUE READING

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A possible role of Homer proteins in neuropsychiatric disorders

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Highly Influential
12 Excerpts

Excessive alcohol consumption sensitizes glutamate transmission: link to Homer proteins and kinase activation

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12 Excerpts

Behavioural and neurochemical phenotyping of Homer1 mutant mice: possible implications for schizophrenia

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20 Excerpts

Homer2 is necessary for ethanolinduced neuroplasticity

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Highly Influential
20 Excerpts

Up, up and away! facilitation of alcoholinduced neural plasticity by Homer over expression

  • KK Szumlinski
  • Alcohol Clin Exp Ther 30(Suppl): 60A
  • 2006
Highly Influential
3 Excerpts

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