Accumbens D2 modulation of sensorimotor gating in rats: assessing anatomical localization.

@article{Wan1994AccumbensDM,
  title={Accumbens D2 modulation of sensorimotor gating in rats: assessing anatomical localization.},
  author={F. J. Wan and Mark A. Geyer and Neal R. Swerdlow},
  journal={Pharmacology, biochemistry, and behavior},
  year={1994},
  volume={49 1},
  pages={155-63}
}
The normal reduction in acoustic startle amplitude caused by a weak prepulse (prepulse inhibition; PPI) is deficient in schizophrenic patients and in rats after systemic or intraaccumbens treatment with the D2 dopamine agonist quinpirole. We examined the anatomical substrates of the PPI-disruptive effects of intraaccumbens quinpirole. PPI was significantly reduced in a dose-dependent manner by quinpirole infusion into the medial accumbens shell region, the lateral accumbens core region, and an… CONTINUE READING

From This Paper

Topics from this paper.
24 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…