Accumbal D1R Neurons Projecting to Lateral Hypothalamus Authorize Feeding

  title={Accumbal D1R Neurons Projecting to Lateral Hypothalamus Authorize Feeding},
  author={Eoin Cornelius O’Connor and Yves Kremer and Sandrine Lefort and Masaya Harada and Vincent Jean Pascoli and Cl{\'e}ment Rohner and Christian L{\"u}scher},
Feeding satisfies metabolic need but is also controlled by external stimuli, like palatability or predator threat. Nucleus accumbens shell (NAcSh) projections to the lateral hypothalamus (LH) are implicated in mediating such feeding control, but the neurons involved and their mechanism of action remain elusive. We show that dopamine D1R-expressing NAcSh neurons (D1R-MSNs) provide the dominant source of accumbal inhibition to LH and provide rapid control over feeding via LH GABA neurons. In… CONTINUE READING
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