Accounting for solvent accessibility and secondary structure in protein phylogenetics is clearly beneficial.

@article{Le2010AccountingFS,
  title={Accounting for solvent accessibility and secondary structure in protein phylogenetics is clearly beneficial.},
  author={Si Quang Le and Olivier Gascuel},
  journal={Systematic biology},
  year={2010},
  volume={59 3},
  pages={277-87}
}
Amino acid substitution models are essential to most methods to infer phylogenies from protein data. These models represent the ways in which proteins evolve and substitutions accumulate along the course of time. It is widely accepted that the substitution processes vary depending on the structural configuration of the protein residues. However, this information is very rarely used in phylogenetic studies, though the 3-dimensional structure of dozens of thousands of proteins has been elucidated… CONTINUE READING

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References

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Showing 1-10 of 42 references

Maximum-likelihood estimation of phylogeny from DNA sequences when substitution rates differ over sites

  • Z. Yang
  • Mol. Biol. Evol. 10:1396–1401.
  • 1993
Highly Influential
4 Excerpts

A new look at statistical model identification

  • H. Akaike
  • IEEE Trans. Automat. Control. 19:716–722.
  • 1974
Highly Influential
3 Excerpts

A model of evolutionary change in proteins

  • M. O. Dayhoff, R. V. Eyck, C. M. Park
  • In: Dayhoff M.O., editor. Atlas of protein…
  • 1972
Highly Influential
4 Excerpts

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