Accounting for linkage in family-based tests of association with missing parental genotypes.

@article{Martin2003AccountingFL,
  title={Accounting for linkage in family-based tests of association with missing parental genotypes.},
  author={Eden R. Martin and M. P. Bass and Elizabeth R. Hauser and Norman L. Kaplan},
  journal={American journal of human genetics},
  year={2003},
  volume={73 5},
  pages={1016-26}
}
In studies of complex diseases, a common paradigm is to conduct association analysis at markers in regions identified by linkage analysis, to attempt to narrow the region of interest. Family-based tests for association based on parental transmissions to affected offspring are often used in fine-mapping studies. However, for diseases with late onset, parental genotypes are often missing. Without parental genotypes, family-based tests either compare allele frequencies in affected individuals with… CONTINUE READING

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