Accordion-Like Honeycombs for Tissue Engineering of Cardiac Anisotropy

  title={Accordion-Like Honeycombs for Tissue Engineering of Cardiac Anisotropy},
  author={George C. Engelmayr and Mingyu Cheng and Christopher John Bettinger and Jeffrey T. Borenstein and Robert S Langer and Lisa E. Freed},
  booktitle={Nature materials},
Tissue-engineered grafts may be useful in myocardial repair; however, previous scaffolds have been structurally incompatible with recapitulating cardiac anisotropy. Here, we use microfabrication techniques to create an accordion-like honeycomb microstructure in poly(glycerol sebacate), which yields porous, elastomeric three-dimensional (3D) scaffolds with controllable stiffness and anisotropy. Accordion-like honeycomb scaffolds with cultured neonatal rat heart cells demonstrated utility through… CONTINUE READING
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