Accommodation of insertion mutations on the surface and in the interior of staphylococcal nuclease.

Abstract

Alignment of homologous amino acid sequences reveals that insertion mutations are fairly common in evolution. Hitherto, the structural consequences of insertion mutations on the surface and in the interior of proteins of known structures have received little attention. We report here the high-resolution X-ray crystal structures of 2 site-directed insertion… (More)

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@article{Keefe1994AccommodationOI, title={Accommodation of insertion mutations on the surface and in the interior of staphylococcal nuclease.}, author={Linda Keefe and S. Quirk and Alan G. Gittis and John E. Sondek and Eaton E. Lattman}, journal={Protein science : a publication of the Protein Society}, year={1994}, volume={3 3}, pages={391-401} }