Accessory subunit KChIP2 modulates the cardiac L-type calcium current.

  title={Accessory subunit KChIP2 modulates the cardiac L-type calcium current.},
  author={Morten B Thomsen and Chaojian Wang and Nazira Őzgen and Hong-gang Wang and Michael R. Rosen and Geoffrey S Pitt},
  journal={Circulation research},
  volume={104 12},
Complex modulation of voltage-gated Ca2+ currents through the interplay among Ca2+ channels and various Ca(2+)-binding proteins is increasingly being recognized. The K+ channel interacting protein 2 (KChIP2), originally identified as an auxiliary subunit for K(V)4.2 and a component of the transient outward K+ channel (I(to)), is a Ca(2+)-binding protein whose regulatory functions do not appear restricted to K(V)4.2. Consequently, we hypothesized that KChIP2 is a direct regulator of the cardiac… CONTINUE READING