Accessory signals in murine cytolytic T cell responses. Dual requirement for IL-1 and IL-6.

Abstract

We have examined the nature of the accessory factors required for the development of primary murine CTL in accessory cell-depleted allogeneic mixed lymphocyte cultures. None of the known macrophage-derived factors was active by itself but the combination of IL-1 and IL-6 induced cytolytic responses equivalent to those of unfractionated cultures. Experiments… (More)

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@article{Renauld1989AccessorySI, title={Accessory signals in murine cytolytic T cell responses. Dual requirement for IL-1 and IL-6.}, author={J C Renauld and Ard A Vink and J L Van Snick}, journal={Journal of immunology}, year={1989}, volume={143 6}, pages={1894-8} }