Accessory gene regulator (agr) locus in geographically diverse Staphylococcus aureus isolates with reduced susceptibility to vancomycin.

@article{Sakoulas2002AccessoryGR,
  title={Accessory gene regulator (agr) locus in geographically diverse Staphylococcus aureus isolates with reduced susceptibility to vancomycin.},
  author={George Sakoulas and George M. Eliopoulos and Robert C. Moellering and Christine B Wennersten and Lata Venkataraman and Richard P. Novick and Howard S. Gold},
  journal={Antimicrobial agents and chemotherapy},
  year={2002},
  volume={46 5},
  pages={1492-502}
}
The majority of infections with glycopeptide intermediate-level resistant Staphylococcus aureus (GISA) originate in biomedical devices, suggesting a possible increased ability of these strains to produce biofilm. Loss of function of the accessory gene regulator (agr) of S. aureus has been suggested to confer an enhanced ability to bind to polystyrene. We studied agr in GISA, hetero-GISA, and related glycopeptide-susceptible S. aureus isolates. All GISA strains from diverse geographic origins… CONTINUE READING
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Whole genome sequencing of methicillin-resistant Staphylococ- cus aureus

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