Accessory cells provide more than one signal for lectin mitogen-stimulated proliferation of human lymphocytes.

@article{Kern1985AccessoryCP,
  title={Accessory cells provide more than one signal for lectin mitogen-stimulated proliferation of human lymphocytes.},
  author={Jeffery A. Kern and Ronald P. Daniele and Peter C. Nowell},
  journal={Journal of leukocyte biology},
  year={1985},
  volume={38 4},
  pages={495-507}
}
A culture system was developed in which human peripheral blood mononuclear cells (PBMC) depleted of Ia-expressing cells did not proliferate in response to the lectin mitogen phytohemagglutinin (PHA). These cells were able to respond to mitogen if purified autologous accessory cells were added back to the culture, thus showing an absolute requirement for Ia-expressing accessory cells in mitogen-driven T-cell proliferation. The identity of these accessory cells was shown to be not only monocytes… CONTINUE READING

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