Accessory cell activity of murine tumor-associated macrophages.

  title={Accessory cell activity of murine tumor-associated macrophages.},
  author={Graeme J. Dougherty and William H. Mcbride},
  journal={Journal of the National Cancer Institute},
  volume={76 3},
The accessory cell activity of macrophages associated with the murine 3-methylcholanthrene-induced fibrosarcoma FSa was investigated. On the basis of Fc receptor expression and phagocytic activity, 20-25% of cells present within enzymatically disaggregated tumor cell suspensions could be classified as macrophages. These cells were approximately 50% I-Ak positive but did not express the Mac-1 antigen. T-cells played an important role in regulating I-Ak expression, and macrophages obtained from… CONTINUE READING

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