Accessory alpha-helix of complexin I can displace VAMP2 locally in the complexin-SNARE quaternary complex.


The calcium-triggered neurotransmitter release requires three SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins: synaptobrevin 2 (or vesicle-associated membrane protein 2) on the synaptic vesicle and syntaxin 1 and SNAP-25 (synaptosome-associated protein of 25 kDa) at the presynaptic plasma membrane. This minimal fusion… (More)
DOI: 10.1016/j.jmb.2009.12.020


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