Accessory Protein Facilitated CFTR-CFTR Interaction, a Molecular Mechanism to Potentiate the Chloride Channel Activity

@article{Wang2000AccessoryPF,
  title={Accessory Protein Facilitated CFTR-CFTR Interaction, a Molecular Mechanism to Potentiate the Chloride Channel Activity},
  author={Shusheng Wang and H. Yue and R. Derin and W. Guggino and M. Li},
  journal={Cell},
  year={2000},
  volume={103},
  pages={169-179}
}
  • Shusheng Wang, H. Yue, +2 authors M. Li
  • Published 2000
  • Biology, Medicine
  • Cell
  • The cystic fibrosis transmembrane conductance regulator (CFTR) gene encodes a chloride channel protein that belongs to the superfamily of ATP binding cassette (ABC) transporters. Phosphorylation by protein kinase A in the presence of ATP activates the CFTR-mediated chloride conductance of the apical membranes. We have identified a novel hydrophilic CFTR binding protein, CAP70, which is also concentrated on the apical surfaces. CAP70 consists of four PDZ domains, three of which are capable of… CONTINUE READING
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