Accessorizing and anchoring the LINC complex for multifunctionality

  title={Accessorizing and anchoring the LINC complex for multifunctionality},
  author={Wakam Chang and Howard J Worman and Gregg G. Gundersen},
  booktitle={The Journal of cell biology},
The linker of nucleoskeleton and cytoskeleton (LINC) complex, composed of outer and inner nuclear membrane Klarsicht, ANC-1, and Syne homology (KASH) and Sad1 and UNC-84 (SUN) proteins, respectively, connects the nucleus to cytoskeletal filaments and performs diverse functions including nuclear positioning, mechanotransduction, and meiotic chromosome movements. Recent studies have shed light on the source of this diversity by identifying factors associated with the complex that endow specific… CONTINUE READING
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