Accessing natural product biosynthetic processes by mass spectrometry.

Abstract

Two important classes of natural products are made by nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs). With most biosynthetic intermediates covalently tethered during biogenesis, protein mass spectrometry (MS) has proven invaluable for their interrogation. New mass spectrometric assay formats (such as selective cofactor ejection and… (More)
DOI: 10.1016/j.cbpa.2008.07.022

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