Accessibility of a glucocorticoid response element in a nucleosome depends on its rotational positioning.

@article{Li1995AccessibilityOA,
  title={Accessibility of a glucocorticoid response element in a nucleosome depends on its rotational positioning.},
  author={Qingqin Li and Orjan Wrange},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 8},
  pages={4375-84}
}
Gene expression requires binding of transcription factors to their cognate DNA response elements, the latter being often integrated into sequence-specifically positioned nucleosomes. To investigate the constraints imposed on factor-DNA recognition by the nucleosomal organization, we studied the binding of glucocorticoid receptor to a single glucocorticoid response element (GRE) displaying four different rotational frames in three different translational positions in reconstituted nucleosomes… CONTINUE READING

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