Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements.

@article{Sleckman1996AccessibilityCO,
  title={Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements.},
  author={Barry P Sleckman and Judith Gorman and Frederick W Alt},
  journal={Annual review of immunology},
  year={1996},
  volume={14},
  pages={459-81}
}
Antigen receptor variable region genes are assembled from germline variable (V), diversity (D), and joining (J) gene segments. This process requires expression of V(D)J recombinase activity, and "accessibility" of variable gene segments to this recombinase. The exact mechanism by which variable gene segments become accessible during development is not known. However, several studies have shown that cis-acting elements that regulate transcription may also function to regulate accessibility. Here… CONTINUE READING

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