Accessibility changes across the mouse Igh-V locus during B cell development.

  title={Accessibility changes across the mouse Igh-V locus during B cell development.},
  author={Brian B. Haines and Peter H. Brodeur},
  journal={European journal of immunology},
  volume={28 12},
During their development, B and T lymphocytes are thought to undergo several cycles of chromatin remodeling at their antigen receptor loci that serve to regulate access of a common V(D)J recombinase to particular gene segments. We used germ-line transcription and susceptibility to DNasel as markers to examine tissue and stage-specific changes in chromatin structure surrounding genes of the VHJ558, VH10, and VHS107 families, whose members are located at discreet subregions of the locus. Germ… CONTINUE READING
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