Access denied? The status of co-receptor inhibition to counter HIV entry

@article{Biswas2007AccessDT,
  title={Access denied? The status of co-receptor inhibition to counter HIV entry},
  author={Priscilla Biswas and G. Tambussi and Adriano Lazzarin},
  journal={Expert Opinion on Pharmacotherapy},
  year={2007},
  volume={8},
  pages={923 - 933}
}
As resistance and long-term metabolic abnormalities hamper the efficacy of previous drugs against HIV-1, targeting of HIV co-receptors represents an exciting new frontier for antiretroviral therapeutics. CCR5 inhibitors are most likely to be the new available drugs within the class of entry inhibitors. This paper reviews the most recent clinical data available on the small-molecule compounds vicriviroc and maraviroc and on the antibodies PRO 140 and CCR5mAb004, as well as some novel genetic… 

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