Accelerative effect of shikonin, alkannin and acetylshikonin on the proliferation of granulation tissue in rats.

@article{Ozaki1994AccelerativeEO,
  title={Accelerative effect of shikonin, alkannin and acetylshikonin on the proliferation of granulation tissue in rats.},
  author={Yukio Ozaki and Akihiko Ohno and Yoshiro Saito and Masako Satake},
  journal={Biological & pharmaceutical bulletin},
  year={1994},
  volume={17 8},
  pages={1075-7}
}
The present study was carried out to compare the accelerative effect of shikonin (R-type), alkannin (S-type), and acetylshikonin on the proliferation of granulation tissue in rats, and to elucidate the correlation between the potency of the effect and their optical activity. Koushikon mainly contained the R-type of acetylshikonin, and Nanshikon mainly contained the S-type of acetylshikonin. Each compound produced a dose-dependent acceleration of the cotton pellet-induced granuloma formation. In… CONTINUE READING