Acceleration of type 1 diabetes by a coxsackievirus infection requires a preexisting critical mass of autoreactive T-cells in pancreatic islets.

@article{Serreze2000AccelerationOT,
  title={Acceleration of type 1 diabetes by a coxsackievirus infection requires a preexisting critical mass of autoreactive T-cells in pancreatic islets.},
  author={David V Serreze and Eric W Ottendorfer and Tamir M. Ellis and Charles J. Gauntt and Mark A Atkinson},
  journal={Diabetes},
  year={2000},
  volume={49 5},
  pages={708-11}
}
Coxsackievirus infections have been proposed as an environmental trigger for the development of T-cell-mediated autoimmune (type 1) diabetes by either providing a molecular mimic of the candidate pancreatic beta-cell autoantigen GAD or inducing bystander inflammation in the pancreas. In this study in the NOD mouse model, we found that infection with a pancreatrophic coxsackievirus isolate can accelerate type 1 diabetes development through the induction of a bystander activation effect, but only… CONTINUE READING
77 Citations
19 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 77 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 19 references

Genetics and immunogenetics of NOD mice and related strains

  • EH Leiter
  • Leiter EH,
  • 1998

NOD mice as a model for therapeutic interventions in human insulin dependent diabetes mellitus

  • MA Atkinson
  • Leiter EH, Atkinson MA,
  • 1998

The possible role of enteroviruses in diabetes mellitus

  • M Rewers, M Atkinson
  • Rotbart HA,
  • 1995

Similar Papers

Loading similar papers…