Acceleration of the proliferative activity of esophageal carcinoma with invasion beyond the muscularis mucosae; immunohistochemical analysis using MIB-1 for the Ki-67 antigen.

@article{Chino2007AccelerationOT,
  title={Acceleration of the proliferative activity of esophageal carcinoma with invasion beyond the muscularis mucosae; immunohistochemical analysis using MIB-1 for the Ki-67 antigen.},
  author={Osamu Chino and Yoshiyuki Osamura and Yoshifumi Kise and Takayuki Nishi and Hideo Shimada and Makiko Tanaka and Hiroshi Kijima and Hiroyasu Makuuchi},
  journal={The Tokai journal of experimental and clinical medicine},
  year={2007},
  volume={32 4},
  pages={115-20}
}
Squamous cell carcinoma of the esophagus with cancer invasion beyond the muscularis mucosae is known to have lymph node metastasis and lymphatic or blood vessel invasion compared with intramucosal carcinoma. In submucosal and T2-3 carcinoma, lymph node and lymphatic/vascular involvement are shown more frequently, leading to a poor prognosis. Therefore, we examined proliferative activity of esophageal squamous cell carcinoma including early carcinoma in relation to clinicopathological findings… CONTINUE READING