Acceleration of rat liver phospholipid metabolism after long-term cadmium administration.

@article{Waku1985AccelerationOR,
  title={Acceleration of rat liver phospholipid metabolism after long-term cadmium administration.},
  author={Keizo Waku and Takashi Shibata and Hiroe Nakazawa and Shohei Yamashina},
  journal={Archives of biochemistry and biophysics},
  year={1985},
  volume={238 2},
  pages={509-16}
}
Male Wistar rats, 6 weeks old, were allowed free access to water containing cadmium chloride at a concentration of 250 ppm as cadmium (Cd) for 6 and 12 months. The growth, as measured by body weight of Cd-treated rats, was significantly retarded. Electron microscopic studies revealed the appearance of small vacuoles in the cytoplasm, and involution of the rough endoplasmic reticulum (RER) in both the liver and whole kidney. When radioactive precursors of phospholipids, H3(32)PO4 and [1(3)-H… CONTINUE READING