Acceleration of peripheral nerve regeneration following FK506 administration.

  title={Acceleration of peripheral nerve regeneration following FK506 administration.},
  author={Sarah C. Jost and Vaishali B. Doolabh and Susan E. Mackinnon and Michelle I-Ching Lee and Daniel A. Hunter},
  journal={Restorative neurology and neuroscience},
  volume={17 1},
Purpose: The severe functional and sensory deficits seen following injury to peripheral nerves makes facilitation of nerve regeneration a primary goal of the reconstructive surgeon. This study examines whether daily administration of FK506 or Cyclosporin A expedites peripheral nerve regeneration following neurotmetic injury in a rat model Methods: Inbred Buffalo rats were randomized to three experimental groups. Group I rats served as untreated controls. Rats in groups II and III received daily… CONTINUE READING


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