Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy.

@article{Conway2000AccelerationOO,
  title={Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy.},
  author={Kelly A. Conway and Soon J Lee and J C Rochet and Tomas T. Ding and Robin E. Williamson and Peter T. Lansbury},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 2},
  pages={571-6}
}
The Parkinson's disease (PD) substantia nigra is characterized by the presence of Lewy bodies containing fibrillar alpha-synuclein. Early-onset PD has been linked to two point mutations in the gene that encodes alpha-synuclein, suggesting that disease may arise from accelerated fibrillization. However, the identity of the pathogenic species and its relationship to the alpha-synuclein fibril has not been elucidated. In this in vitro study, the rates of disappearance of monomeric alpha-synuclein… CONTINUE READING
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