Acceleration of matrix metalloproteinase-1 production and activation of platelet-derived growth factor receptor beta in human coronary smooth muscle cells by oxidized LDL and 4-hydroxynonenal.

@article{Akiba2006AccelerationOM,
  title={Acceleration of matrix metalloproteinase-1 production and activation of platelet-derived growth factor receptor beta in human coronary smooth muscle cells by oxidized LDL and 4-hydroxynonenal.},
  author={Satoshi Akiba and Satomi Kumazawa and Hidenori Yamaguchi and Naoya Hontani and Takeyoshi Matsumoto and Takako Ikeda and Mayuko Oka and Takashi Sato},
  journal={Biochimica et biophysica acta},
  year={2006},
  volume={1763 8},
  pages={797-804}
}
Increases in matrix metalloproteinases (MMPs) at atherosclerotic lesions are involved in the migration of smooth muscle cells (SMCs) into the intima and to the rupture of plaques, being implicated in the progression of atherosclerosis. The present study examined the mechanisms underlying the production of MMP-1, interstitial collagenase-1, induced by oxidized low-density lipoprotein (oxLDL) and 4-hydroxynonenal (4-HNE), factors proposed to play a pivotal role in atherogenesis, in human coronary… CONTINUE READING

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