Acceleration of emergence of bacterial antibiotic resistance in connected microenvironments.

Abstract

The emergence of bacterial antibiotic resistance is a growing problem, yet the variables that influence the rate of emergence of resistance are not well understood. In a microfluidic device designed to mimic naturally occurring bacterial niches, resistance of Escherichia coli to the antibiotic ciprofloxacin developed within 10 hours. Resistance emerged with… (More)
DOI: 10.1126/science.1208747

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