Acceleration of cartilage repair by genetically modified chondrocytes over expressing bone morphogenetic protein-7.

@article{Hidaka2003AccelerationOC,
  title={Acceleration of cartilage repair by genetically modified chondrocytes over expressing bone morphogenetic protein-7.},
  author={Chisa Hidaka and Laurie R. Goodrich and Chih-Tung Chen and Russell F. Warren and Ronald G. Crystal and Alan J. Nixon},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2003},
  volume={21 4},
  pages={573-83}
}
BACKGROUND Cartilage has a limited capacity to heal. Although chondrocyte transplantation is a useful therapeutic strategy, the repair process can be lengthy. Previously we have shown that over expression of bone morphogenetic protein-7 (BMP-7) in chondrocytes by adenovirus-mediated gene transfer leads to increased matrix synthesis and cartilage-like tissue formation in vitro. In this context we hypothesized that implantation of genetically modified chondrocytes expressing BMP-7 would… CONTINUE READING
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