Acceleration of Gastric Tumorigenesis Through MKRN1-Mediated Posttranslational Regulation of p14ARF

@inproceedings{Ko2012AccelerationOG,
  title={Acceleration of Gastric Tumorigenesis Through MKRN1-Mediated Posttranslational Regulation of p14ARF},
  author={Aram Ko and J Y Shin and Jinho Seo and Kang-Duck Lee and Eun-Woo Lee and Min-Sik Lee and Han Woong Lee and Il Ju Choi and Jin Sook Jeong and K. W. Chun and Jaewhan Song},
  booktitle={Journal of the National Cancer Institute},
  year={2012}
}
BACKGROUND We investigated whether Makorin ring finger protein 1 (MKRN1), an E3 ligase, affects p14ARF-associated cellular senescence and tumorigenesis by posttranslational modification in gastric tumorigenesis. METHODS A link between MKRN1 and ARF was examined in MKRN1 null mouse embryonic fibroblasts (MEFs) and in human fibroblasts and gastric cancer cells by silencing MKRN1 using small interfering RNA (siRNA) and short hairpin RNA (shRNA). Ubiquitination and proteasomal degradation assays… CONTINUE READING
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