Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia.

@article{Planel2009AccelerationAP,
  title={Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia.},
  author={Emmanuel Planel and Alexis Bretteville and Li Liu and L{\'a}szl{\'o} Vir{\'a}g and Angela L Du and Wai Haung Yu and Dennis W. Dickson and Robert A. Whittington and Karen E Duff},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2009},
  volume={23 8},
  pages={2595-604}
}
Alzheimer's disease and other tauopathies are characterized by the presence of intracellular neurofibrillary tangles composed of hyperphosphorylated, insoluble tau. General anesthesia has been shown to be associated with increased risk of Alzheimer's disease, and we have previously demonstrated that anesthesia induces hypothermia, which leads to overt tau hyperphosphorylation in the brain of mice regardless of the anesthetic used. To investigate whether anesthesia enhances the long-term risk of… CONTINUE READING