Accelerated wound healing in mice with a disruption of the thrombospondin 2 gene.

@article{Kyriakides1999AcceleratedWH,
  title={Accelerated wound healing in mice with a disruption of the thrombospondin 2 gene.},
  author={Themis R Kyriakides and James W Tam and Paul Bornstein},
  journal={The Journal of investigative dermatology},
  year={1999},
  volume={113 5},
  pages={782-7}
}
Mice that lack the extracellular matrix protein thrombospondin 2 have, among several abnormalities, an increase in vascular density, abnormal collagen fibrils, and dermal fibroblasts that are defective in adhesion. These findings suggested that responses involving these processes, such as wound healing, might be altered. To investigate the healing process, excisional wounds were made with the aid of a biopsy punch. Such wounds, observed over a 14 d period, appeared to heal at an accelerated… CONTINUE READING
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