Accelerated tumor progression in mice lacking the ATP receptor P2X7.

  title={Accelerated tumor progression in mice lacking the ATP receptor P2X7.},
  author={E Adinolfi and Marina Capece and Alessia Franceschini and Simonetta Falzoni and Anna Lisa Giuliani and Alessandra Rotondo and Alba Clara Sarti and Massimo Bonora and Susanne Syberg and Domenica Maria Corigliano and Paolo Pinton and Niklas Rye Jorgensen and Luigi Abelli and Laura Emionite and Lizzia Raffaghello and Vito Pistoia and Francesco Di Virgilio},
  journal={Cancer research},
  volume={75 4},
The ATP receptor P2X7 (P2X7R or P2RX7) has a key role in inflammation and immunity, but its possible roles in cancer are not firmly established. In the present study, we investigated the effect of host genetic deletion of P2X7R in the mouse on the growth of B16 melanoma or CT26 colon carcinoma cells. Tumor size and metastatic dissemination were assessed by in vivo calliper and luciferase luminescence emission measurements along with postmortem examination. In P2X7R-deficient mice, tumor growth… CONTINUE READING
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