Accelerated thrombolysis in a rabbit model of carotid artery thrombosis with liposome-encapsulated and microencapsulated streptokinase.

@article{Leach2003AcceleratedTI,
  title={Accelerated thrombolysis in a rabbit model of carotid artery thrombosis with liposome-encapsulated and microencapsulated streptokinase.},
  author={J Kent Leach and Edgar A. O'Rear and Eugene Patterson and Yiwei Miao and Arthur E. Johnson},
  journal={Thrombosis and haemostasis},
  year={2003},
  volume={90 1},
  pages={64-70}
}
The present study compares the efficacy of two formulations of encapsulated streptokinase to streptokinase in a rabbit model of carotid artery thrombosis. Arterial thrombosis followed the injection of thrombin mixed with autologous whole blood into a carotid artery of New Zealand white rabbits. Thirty minutes after the confirmation of an occlusive thrombus, one of four streptokinase formulations was infused at a dosage of 6000 IU/kg into the jugular vein. Free streptokinase (FREE SK) was… CONTINUE READING
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