Accelerated telomere shortening in ataxia telangiectasia

@article{Metcalfe1996AcceleratedTS,
  title={Accelerated telomere shortening in ataxia telangiectasia},
  author={Judith A. Metcalfe and Julian Parkhill and Louise Leonard Campbell and Michael B. Stacey and Paul Biggs and Philip J. Byrd and Alexander Malcolm R. Taylor},
  journal={Nature Genetics},
  year={1996},
  volume={13},
  pages={350-353}
}
Ataxia telangiectasia (AT) is characterized by neurological deterioration, immunodeficiency, spontaneous chromosomal instability, hypersensitivity to ionizing radiation, predisposition to cancer, particularly T cell leukaemia and lymphoma, and premature ageing1. The most commonly observed defect affecting telomeres in humans is telomeric fusions, particularly in T lymphocytes in AT patients2–4. Rarely, some tumour cells5–11, like senescent cells12, have dicentric chromosomes that may arise as a… CONTINUE READING
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