Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease

@article{Saul2013AcceleratedTP,
  title={Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease},
  author={Anika Saul and Frederik Sprenger and T. A. Bayer and Oliver Wirths},
  journal={Neurobiology of Aging},
  year={2013},
  volume={34},
  pages={2564-2573}
}
There is pivotal evidence that tau pathology can be triggered by amyloid-β (Aβ) pathology in experimental systems. On the other side, studies on human brain specimen have elucidated that tau pathology may occur before amyloid pathology is present indicating that in principle tau pathology could also trigger Aβ aggregation. To address this question, we have crossed 5XFAD mice coexpressing human mutant APP695 with the Swedish, Florida, and London mutations and human mutant presenilin-1 (PS1) with… CONTINUE READING

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