Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation.

@article{Gewirtz2008AcceleratedSA,
  title={Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation.},
  author={David Gewirtz and Shawn E. Holt and Lynne W. Elmore},
  journal={Biochemical pharmacology},
  year={2008},
  volume={76 8},
  pages={947-57}
}
Treatment of malignancies with chemotherapeutic drugs and/or radiotherapy is designed to eliminate the disease by depriving the tumor cell of its reproductive potential. Frequently, the desired effect of cell killing is achieved through the promotion of apoptosis; however, accumulating evidence suggests that apoptosis may not be the exclusive or even primary mechanism whereby tumor cells lose their self-renewal capacity after radiation or drug treatment, particularly in the case of solid tumors… CONTINUE READING

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While failure to undergo apoptosis in response to chemotherapeutic drugs or radiation may represent a mechanism of drug and radiation resistance , particularly in the case of leukemias and lymphomas , it is gradually being recognized that in the case of solid tumors , loss of reproductive capacity can occur through alternative pathways including reproductive cell death or mitotic catastrophe , through autophagic cell death , and as described below , through a terminally arrested state similar to replicative senescence .
While failure to undergo apoptosis in response to chemotherapeutic drugs or radiation may represent a mechanism of drug and radiation resistance , particularly in the case of leukemias and lymphomas , it is gradually being recognized that in the case of solid tumors , loss of reproductive capacity can occur through alternative pathways including reproductive cell death or mitotic catastrophe , through autophagic cell death , and as described below , through a terminally arrested state similar to replicative senescence .
While failure to undergo apoptosis in response to chemotherapeutic drugs or radiation may represent a mechanism of drug and radiation resistance , particularly in the case of leukemias and lymphomas , it is gradually being recognized that in the case of solid tumors , loss of reproductive capacity can occur through alternative pathways including reproductive cell death or mitotic catastrophe , through autophagic cell death , and as described below , through a terminally arrested state similar to replicative senescence .
While failure to undergo apoptosis in response to chemotherapeutic drugs or radiation may represent a mechanism of drug and radiation resistance , particularly in the case of leukemias and lymphomas , it is gradually being recognized that in the case of solid tumors , loss of reproductive capacity can occur through alternative pathways including reproductive cell death or mitotic catastrophe , through autophagic cell death , and as described below , through a terminally arrested state similar to replicative senescence .
While failure to undergo apoptosis in response to chemotherapeutic drugs or radiation may represent a mechanism of drug and radiation resistance , particularly in the case of leukemias and lymphomas , it is gradually being recognized that in the case of solid tumors , loss of reproductive capacity can occur through alternative pathways including reproductive cell death or mitotic catastrophe , through autophagic cell death , and as described below , through a terminally arrested state similar to replicative senescence .
While failure to undergo apoptosis in response to chemotherapeutic drugs or radiation may represent a mechanism of drug and radiation resistance , particularly in the case of leukemias and lymphomas , it is gradually being recognized that in the case of solid tumors , loss of reproductive capacity can occur through alternative pathways including reproductive cell death or mitotic catastrophe , through autophagic cell death , and as described below , through a terminally arrested state similar to replicative senescence .
While failure to undergo apoptosis in response to chemotherapeutic drugs or radiation may represent a mechanism of drug and radiation resistance , particularly in the case of leukemias and lymphomas , it is gradually being recognized that in the case of solid tumors , loss of reproductive capacity can occur through alternative pathways including reproductive cell death or mitotic catastrophe , through autophagic cell death , and as described below , through a terminally arrested state similar to replicative senescence .
While failure to undergo apoptosis in response to chemotherapeutic drugs or radiation may represent a mechanism of drug and radiation resistance , particularly in the case of leukemias and lymphomas , it is gradually being recognized that in the case of solid tumors , loss of reproductive capacity can occur through alternative pathways including reproductive cell death or mitotic catastrophe , through autophagic cell death , and as described below , through a terminally arrested state similar to replicative senescence .
While failure to undergo apoptosis in response to chemotherapeutic drugs or radiation may represent a mechanism of drug and radiation resistance , particularly in the case of leukemias and lymphomas , it is gradually being recognized that in the case of solid tumors , loss of reproductive capacity can occur through alternative pathways including reproductive cell death or mitotic catastrophe , through autophagic cell death , and as described below , through a terminally arrested state similar to replicative senescence .
While failure to undergo apoptosis in response to chemotherapeutic drugs or radiation may represent a mechanism of drug and radiation resistance , particularly in the case of leukemias and lymphomas , it is gradually being recognized that in the case of solid tumors , loss of reproductive capacity can occur through alternative pathways including reproductive cell death or mitotic catastrophe , through autophagic cell death , and as described below , through a terminally arrested state similar to replicative senescence .
While failure to undergo apoptosis in response to chemotherapeutic drugs or radiation may represent a mechanism of drug and radiation resistance , particularly in the case of leukemias and lymphomas , it is gradually being recognized that in the case of solid tumors , loss of reproductive capacity can occur through alternative pathways including reproductive cell death or mitotic catastrophe , through autophagic cell death , and as described below , through a terminally arrested state similar to replicative senescence .
While failure to undergo apoptosis in response to chemotherapeutic drugs or radiation may represent a mechanism of drug and radiation resistance , particularly in the case of leukemias and lymphomas , it is gradually being recognized that in the case of solid tumors , loss of reproductive capacity can occur through alternative pathways including reproductive cell death or mitotic catastrophe , through autophagic cell death , and as described below , through a terminally arrested state similar to replicative senescence .
While failure to undergo apoptosis in response to chemotherapeutic drugs or radiation may represent a mechanism of drug and radiation resistance , particularly in the case of leukemias and lymphomas , it is gradually being recognized that in the case of solid tumors , loss of reproductive capacity can occur through alternative pathways including reproductive cell death or mitotic catastrophe , through autophagic cell death , and as described below , through a terminally arrested state similar to replicative senescence .
While failure to undergo apoptosis in response to chemotherapeutic drugs or radiation may represent a mechanism of drug and radiation resistance , particularly in the case of leukemias and lymphomas , it is gradually being recognized that in the case of solid tumors , loss of reproductive capacity can occur through alternative pathways including reproductive cell death or mitotic catastrophe , through autophagic cell death , and as described below , through a terminally arrested state similar to replicative senescence .
While failure to undergo apoptosis in response to chemotherapeutic drugs or radiation may represent a mechanism of drug and radiation resistance , particularly in the case of leukemias and lymphomas , it is gradually being recognized that in the case of solid tumors , loss of reproductive capacity can occur through alternative pathways including reproductive cell death or mitotic catastrophe , through autophagic cell death , and as described below , through a terminally arrested state similar to replicative senescence .
While failure to undergo apoptosis in response to chemotherapeutic drugs or radiation may represent a mechanism of drug and radiation resistance , particularly in the case of leukemias and lymphomas , it is gradually being recognized that in the case of solid tumors , loss of reproductive capacity can occur through alternative pathways including reproductive cell death or mitotic catastrophe , through autophagic cell death , and as described below , through a terminally arrested state similar to replicative senescence .
While failure to undergo apoptosis in response to chemotherapeutic drugs or radiation may represent a mechanism of drug and radiation resistance , particularly in the case of leukemias and lymphomas , it is gradually being recognized that in the case of solid tumors , loss of reproductive capacity can occur through alternative pathways including reproductive cell death or mitotic catastrophe , through autophagic cell death , and as described below , through a terminally arrested state similar to replicative senescence .
Neoplastic CellIs abnormal cell of diseaseNeoplasms
Treatment of malignancies with chemotherapeutic drugs and/or radiotherapy is designed to eliminate the disease by depriving the tumor cell of its reproductive potential .
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