Accelerated replicative senescence of medial smooth muscle cells derived from abdominal aortic aneurysms compared to the adjacent inferior mesenteric artery.

@article{Liao2000AcceleratedRS,
  title={Accelerated replicative senescence of medial smooth muscle cells derived from abdominal aortic aneurysms compared to the adjacent inferior mesenteric artery.},
  author={Steve M. Liao and John A Curci and B. J. Kelley and Gregorio A. Sicard and Robert W Thompson},
  journal={The Journal of surgical research},
  year={2000},
  volume={92 1},
  pages={85-95}
}
BACKGROUND Abdominal aortic aneurysms (AAAs) are associated with aging and atherosclerosis. AAAs arise through a degenerative process characterized in part by depletion of medial smooth muscle cells (SMC), suggesting that generalized aging and SMC senescence represent potential mechanisms contributing to aneurysmal degeneration. It is not yet known whether SMC from AAA tissue exhibit a difference in proliferative capacity compared to SMC from nonaneurysmal vessels or to what extent such… CONTINUE READING