Accelerated neuronal differentiation induced by p53 suppression.

  title={Accelerated neuronal differentiation induced by p53 suppression.},
  author={Ana C{\'a}ssia S Ferreira and Kenneth S. Kosik},
  journal={Journal of cell science},
  volume={109 ( Pt 6)},
p53, a tumor suppressor gene product, has been implicated in the control of cell growth and malignant transformation in different cell types. Here we studied the role of p53 in normal central nervous system development. We show that p53 is expressed in neuroblasts and is down regulated when migrating neurons reach their destination. The suppression of p53 either by the addition of antisense oligonucleotides to culture medium or by the culture of neurons from p53-/- mice accelerated their… CONTINUE READING
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