Accelerated natriuresis induced by synthetic atrial natriuretic polypeptide in spontaneously hypertensive rats.

@article{Kihara1985AcceleratedNI,
  title={Accelerated natriuresis induced by synthetic atrial natriuretic polypeptide in spontaneously hypertensive rats.},
  author={Minoru Kihara and Kunio Nakayama and K. Nakao and Aya Sugawara and Narito Morii and Masakatsu Sakamoto and Masayuki Suda and M Shimokura and Yoshiaki Kiso and Hiroo Imura},
  journal={Clinical and experimental hypertension. Part A, Theory and practice},
  year={1985},
  volume={7 4},
  pages={539-51}
}
Effects of synthetic alpha human atrial natriuretic polypeptide (alpha-hANP) on diuresis, natriuresis and mean arterial blood pressure (MAP) were compared between 4-5 month-old male spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) under ether anesthesia. In both groups, the peptide injected (0.5 micrograms/100g body weight, i.v.) caused potent (about ten fold), rapid and short-acting (for 15 min) increases in sodium (Na+) and chloride excretions and also an increase in urine… CONTINUE READING